Use of combined IV intraarticular TXA linked with reduced blood loss in TKA

Patients who underwent total knee arthroplasty and received both IV and intra-articular administration of tranexamic acid had a clinically relevant 37% reduction in blood loss at 24 hours and 48 hours postoperatively compared with patients who received only intravenous administration of tranexamic acid, according to results of a randomized, double-blind placebo-controlled study of 60 patients from Denmark.